Organophosphate (OP) poisoning is a major toxicological problem in Kenya.
Majority of poisoning cases seen in our hospitals results from pesticide exposures of chemicals commonly used for controlling pests in homes and farms. Such OPs include acaricides such as Duodip, and insecticides such as diazinon.
OP compounds acts through overexcitation of the nervous system leading to tremors, muscular fasciculations, agitation, respiratory depression, and seizures.
A number of drugs are used to manage acute poisoning with OPs. The antidepressant diazepam has been beneficial in severe OP poisoning when administered as an adjunct to atropine therapy.
Animal experiments show that combined atropine . . .
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