- Eprinomectin is a broad-spectrum avermectin topical endectocide (kills both endoparasites (internal worms) and ectoparasites (external ticks, lice, mosquitoes)
- They act as an agonist of the GABA receptors in nerve cells and selectively bind to glutamate-gated chloride ion channels in the nerves and muscle cells of the parasites and finally prevent transmission of electrical impulse in the muscle and nerves of invertebrates.
- In animals and parasites, the release of GABA (glutamate-gated chloride ion channels are absent in vertebrates) and its postsynaptic binding to its receptor increases the flow of chloride ions in . . .
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