- Moxidectin, a milbemycin closely related to the avermectin group, is a semi-synthetic macrocyclic lactone anthelmintic administered orally, topically, and subcutaneously to treat internal (helminths) and external parasites (mites and ticks) in livestock and companion animals. It is a derivative of abamectin and belongs to the macrocyclic lactone class of compounds.
- Like other macrocyclic lactones, moxidectin acts as a γ‑aminobutyric acid (GABA) agonist in the central nervous system. It stimulates the presynaptic release of GABA and enhances its postsynaptic binding to receptors. This increases chloride ion influx into neurons, resulting in hyperpolarization of cell membranes and . . .
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