Toxicology
- Based on the substituent attached to the phosphorus via a double bond, organophosphorus compounds (OPs) can be divided into phosphates (P=O) or phosphorothioates (P=S) (Costa GL 2008)
- Most OPs are phosphorothioates and have to be activated in vivo to their oxygen analogs (oxones) before they can exert their toxic action. As a consequence, the clinical manifestation of phosphorothioate intoxication in most cases is delayed unless oxidation occurs before administration. The activation rates of the different OP compounds range from very fast (e.g., from parathion to paraoxon in 10 to 20 minutes) to . . .
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