The first sulfonylurea herbicides were introduced in 1982 and have been used for control of broadleaf weeds and grasses.
These herbicides act by disrupting protein synthesis via inhibition of acetolactate synthase (ALSase) enzyme (also known as acetohydroxyacid synthase), a key enzyme in the synthesis of branched amino acid (i.e. valine, leucine, isoleucine)
After oral administration in rats , it is extensively absorbed and widely distributed with peak concentrations in blood occurring within 0.5 hours, indicating rapid absorption (EACHA, 2016).
The concentrations of halosulfuron-methyl are reportedly highest in the plasma, kidney and liver
The compound is eliminated slowly in . . .
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