Toxicology
Pyrazole herbicides pyrazolate and pyrazoxyfen have been widely used for annual and perennial weed control in paddy rice.
other pyrazole herbicides include azimsulfuron cyclopyranil difenzoquat halosulfuron metazachlor metazosulfuron pyraclonil pyrazosulfuron pyroxasulfone
Pyrazole herbicides inhibit 4-hydroxyphenylpyruvate dioxygenase (HPPD which catalyzes the oxidation and decarboxylation of the intermediate of tyrosine degradation, 4-hydroxylphenylpyruvic acid, to homogentisic acid) after conversion to the herbicidally active metabolite in aqueous solution and/or in plants (Matsumoto H, 2004)
Compounds able to interfere with HPPD activity (e.g nitisinone originally under development as an herbicide) have been used for the treatment of the . . .
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