- Cymoxanil is an acetamide fungicide that has local systemic activity and is usually formulated with other fungicides.
- The mechanism of action of cymoxanil in plants includes inhibition of nucleic acid synthesis, reduction of cell membrane permeability, inhibition of respiration, and disruption of serine, glycine, and cysteine synthesis. Cymoxanil appears to target RNA biosynthesis through the inhibition of dihydrofolate reductase DHFR that converts dihydrofolate to tetrahydrofolate. The resulting THF acts as a carbon donor to key metabolites, including purines. A dose-dependent reduction of rRNA in response was observed with cymoxanil (United States Environmental Protection Agency, 2016 . . .
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