- Sarolaner is an acaricide and insecticide belonging to the isoxazoline family.
- It is an oral medication marketed as Simparica and Simparica Trio for dogs; used monthly to kill fleas and ticks.
- The primary target of action of sarolaner in insects and acarines is functional blockade of ligand-gated chloride channels (GABA-receptors and glutamate-receptors) in their central nervous system and the neuromuscular junctions. This binding blocks the influx of chloride ions, which normally inhibit nerve impulses, thus resulting in increased nerve stimulation and death of the target parasite (Hergert JJ and Fellman CL . . .
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