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PoisonSense Blog

PoisonSense Blog

WHY ADMINISTERING AN IV DRUG TOO QUICKLY MAY BE DANGEROUS

June 13, 2023 - by Poison Sense

1. Too rapid administration of drugs having a high volume of distribution results in a transiently toxic blood concentrations that may injure or overstimulate organs such as the heart to …

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PoisonSense Blog

SEVERE DIARRHOEA AND DIGOXIN TOXICITY 

June 13, 2023June 13, 2023 - by Poison Sense

Did you know that patients on long term use of digoxin could experience severe digoxin toxicity if they suffer severe fluid loss through intense vomiting and diarrhea? Such a toxicity …

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PoisonSense Blog

WHY YOU WANT TO CONSIDER ATYPICAL ANTIPSYCHOTICS FOR PSYCHOSIS

June 13, 2023June 13, 2023 - by Poison Sense

For most patients with schizophrenia and bipolar disorder with psychotic features, typical and atypical antipsychotics (eg chlorpromazine, haloperidol) are of equal efficacy for treating positive symptoms (Feelings or behaviors that …

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PoisonSense Blog

WHY ORAL GLUCOSE PROVOKE LESS HYPERGLYCEMIA THAN INTRAVENOUS GLUCOSE?

June 13, 2023 - by Poison Sense

Oral glucose, unlike intravenous glucose, enhances secretion of endogenous insulin secretagogues which then amplify the glucose- induced insulin secretion. So, for the same amount of glucose, parenterally administered glucose is …

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PoisonSense Blog

TOXIC OVERDOSE EFFECTS OF ANTIEPILEPTICS , TRICYCLIC ANTIDEPRESSANTS AND ANTIPSYCHOTICS.

June 13, 2023 - by Poison Sense

Antiepileptics such as carbamazepine; Tricyclic antidepressants such as amitriptiline; and most antipsychotics cause blockade of voltage gated sodium channels in the heart associated with QT wave prolongation. The ECG changes …

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PoisonSense Blog

TREATMENT OF ALFA- GLUCOSIDASE INHIBITOR OVERDOSE 

June 13, 2023 - by Poison Sense

Alfa- glucosidase inhibitors such as Acarbose, Miglitol and Voglibose that act on the gastrointestinal tract to interfere with carbohydrate digestion are used as oral antidiabetics. An overdose from these drugs …

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PoisonSense Blog

MERCURY POISONING IN GOLD MINES

June 13, 2023 - by Poison Sense

Elemental mercury is used by artisanal and small-scale miners in gold production in gold mines in Migori and other areas in western Kenya. The pattern of clinical intoxication from mercury …

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PoisonSense Blog

THE TOXICOLOGY OF ALCOHOL

June 13, 2023 - by Poison Sense

Alcohol is a small water soluble molecule that’s absorbed rapidly from the gastrointestinal tract but whose absorption is delayed by presence of food in the stomach. Because of its relative …

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PoisonSense Blog

HOW TO PREVENT SNAKE BITE

June 13, 2023June 13, 2023 - by Poison Sense

The majority of snakes are fearful of humans and would rather flee than confront people. However, if a snake feels threatened they will bite. You can prevent the majority of …

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PoisonSense Blog

THE TRUTH ABOUT SHISHA SMOKING  

June 13, 2023 - by Poison Sense

Shisha smoke, just as cigarette smoke contains toxic agents such as nicotine, carbon monoxide, heavy metals, tar and cancer-causing chemicals like benzene. Although some nicotine is absorbed by water in …

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Hi, I am Dr. Bundo, Msc in pharmacology and Toxicology.
This site is here to bring clinical toxicology information to the public domain.

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