Corticosteroids affects all of the major systems of the body.The effects are higher when given by routes involving general blood circulation like oral, intramuscular, intravenous route.
Prolonged use of corticosteroids such as prednisone lead to peptic ulceration, growth retardation in children, diabetic-like state, hypertension, loss of muscle and bone mass, kidney stones, thinning of the skin and adrenocortical insufficiency up on discontinuation.
The asthma preparations for inhalation such as beclomethasone or fluticasone that act locally at the respiratory mucosa are effective are safer because they are poorly absorbed into the circulation. They are thus preferred compared to their . . .
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