Carbidopa/levodopa combination, also known as levocarb and co-careldopa is primarily used to manage the symptoms of Parkinson's disease even when it does not change the course of the disease.
Levodopa (prodrug) is converted to dopamine by the action of DOPA decarboxylase both in the peripheral circulation and in the central nervous system. But it is only through the activation of central dopamine receptors that improves the symptoms of Parkinson's disease. Activation of peripheral dopamine receptors produces the adverse effects of anorexia, nausea and vomiting associated with levodopa therapy. For this reason, levodopa is usually administered in . . .
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