Toxicology
• They are selective, stomach acting with some contact action (PPDB, 2015).
• Nereistoxins were initially thought to produce a postsynaptic nicotinic acetylcholine receptor anatagonist activity which can lead to the convulsions, respiratory failure and the subsequent death in severe cases.(PPDB, 2015;Gupta et al. 2015).
• Thiocyclam is moderately acutely toxic in mammals (rat oral LD50 399) (PPDB, 2015).
• Recent studies show that Nereistoxins Cartap may produce toxicity through the influx of extracellular Ca(2+) and the release of internal Ca(2+), with subsequent induction of muscular contracture in the diaphragm and other cartap-induced skeletal muscle contracture. This causes . . .
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