Toxicology
The sources of CO may external or internal. Internal exposures to carbon monoxide occur as a result of production of carbon monoxide from endogenous compounds (e.g., heme degradation, auto-oxidation of phenols, photo-oxidation of organic compounds, and lipid peroxidation of cell membrane lipids) and from oxidative metabolism of exogenous compounds (e.g., carbon tetrachloride, dichloromethane, and other dihalomethanes) (ATSDR, 2012).
Carbon monoxide (CO) is both a poison and an essential endogenous regulatory compound of various physiological systems including brain and muscle oxygen storage and utilization (myoglobin, neuroglobin), relaxation of vascular and extra-vascular smooth muscle, modulation of . . .
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