Toxicology
• Thiourea insecticides include chloromethiuron and Diafenthiuron
• Diafenthiuron comps indicate low toxicity following single doses of the undiluted product (Oral LD50 = 1950 mg/kg; Dermal LD50 = >4000 mg/kg) (Safety Data Sheet, 2010;PPDB, 2010)
• Acts by inhibiting oxidative phosphorylation possibly through inhibition of mitochondrial ATPase (Ruder et al.,1991; PPDB, 2014)
• Diafenthiuron is a pro-insecticide and must first be activated by cytochrome P450 to the pesticidal carbodiimide analoque (Ruder et al.,1991)
• Thiourea is an antioxidant (World Health Organization, 2003)
• It is well absorbed orally and is excreted largely unchanged via the kidneys (World Health Organization, 2003 . . .
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