Toxicology
• Carbamates include methomyl,pirimicarb carbofuran, aldicarb
They are clinically similar to but chemically different from organophosphates.
Carbamate insecticides, like the OP insecticides, inhibit AChE and elicit cholinergic hyperstimulation. However, carbamates cause only reversible inhibition of AChE because the carbamylated enzyme is rapidly reactivation in the presence of water. Thus, AChE inhibition by carbamates lasts only minutes or hours. Because of the transient inhibition of AChE, acute intoxication by carbamates generally resolves within a few hours (Bjørling-Poulsen et al., 2008)
In addition, the carbamylated enzyme does not undergo the aging process (Costa GL 2008)
Some carbamates (eg carbofuran . . .
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