Toxicology
• The trimethyl and triethyltin compounds are well absorbed from the gastrointestinal tract and are the most toxic in this group (Kimbrough R D, 1976).
• Some butyltin compounds are known to produce gastrointestinal irritation, even gastroenteritis (IPCS, 1980).
• Some trialkyltin compounds produce a characteristic lesion in the central nervous system consisting of oedema throughout the white matter- trimethyl- and triethyltin compounds are more potent in inducing this lesion (IPCS, 1980).
• Bile duct injury and steatosis of the liver cells has been noted in experimental animals (IPCS, 1980).
• The mode of action of trisubstituted organotins, such as Du-Ter and Plictran . . .
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