Toxicology
• These herbicides are generally only slightly toxic to freshwater fish and invertebrates, and practically nontoxic to wildfowl and other mammals (Kegley et al, 2014)
• Sulfonylureas inhibit the plant enzyme, acetolactate synthase which is speci¢c for plants and mi- • croorganisms, resulting in impaired branch chain amino acid synthesis-valine, leucine and isoleucine (Roberts and Reigart, 2013). • The sulfonylurea herbicides have low application rates compared to traditional herbicides, and have low toxicity to humans and animals (Kegley et al, 2014).
Clinical Manifestation
• Many substituted ureas are irritating to eyes, skin and mucous membranes (Recognition and Management of Pesticide Poisoning).
Severe . . .
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