Whereas fever is a raised body temperature as a result of the hypothalamus setting a higher body temperature set point, hyperthermia is an hypermetabolic state that result in the core body temperature exceeding the thermoregulatory set point.
Antipyretics (eg, paracetamol, aspirin, other NSAIDS drugs) are effective against fever because they reduce the elevated temperature set point within the hypothalamus. In contrast, antipyretics are not effective against hyperthermia, or even heat stroke, mainly because the elevated temperature is not as a result of a higher set point by the hypothalamus.
Antipyretics actually may be harmful in patients who develop hepatic, hematologic . . .
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