The pattern of toxic injury to organ and tissues is affected by the following factors:
- The toxic injury depends largely on the pattern of blood flow to that tissue or organ so that cells in areas that normally have low oxygenation are at increased risk of injury from toxicants that reduce blood flow or oxygen delivery.
- Variations in cell type and function can affect the pattern of toxicant-induced injury so that cells with large capacity for metabolism of xenobiotics will be at higher risk for injury by toxicants requiring bioactivation.
The nephron, basic . . .
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