Metsulfuron methyl is a residual sulfonyl urea that inhibits the biosynthesis of branched amino acids by competitively binding to the enzyme system which catalyzes the formation of these amino acids, the acetolactate synthase (ALS)
Metsulfuron methyl is classified by the Environmental Protection Agency in acute Toxicity Category III; it has low acute toxicity
Low acute toxicity was observed when metsulfuron-methyl is administered by the oral, dermal or inhalation routes. No skin or eye irritation and no potential for skin sensitisation were attributed to the active substance (EFSA, 2015).
Metsulfuron-methyl is almost completely absorbed after oral administration (EFSA, 2015 . . .
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