CARBAMATES & 2-PAM.

Correctly diagnosing cholinergic syndrome is not enough. Knowing that intoxication of carbamates (methomyl, pirimicarb carbofuran, aldicarb), and organophosphates generates similar clinical profile isn't enough too.

It's sufficient though to know that oximes such as 2-PAM, binds transiently to acetylcholinesterase just as carbamates hence enhances carbamate poisoning. Therefore, 2-PAM is contraindicated in carbamate intoxication. This is in contrast to organophosphate's where it is an antidote

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