Toxicology
• Quaternary ammonium compounds (QACs) are poorly absorbed by oral route and therefore relatively large amounts are eliminated in faeces (Craig & Stitzel, 1994 cited by IPCS, 1999)
• They are caustic agents which causes mucosal necrosis through disruption of lipid bi-layer(IPCS, 1999;Environmental Project No. 555 2000)
) • Quaternary ammonium compounds have curare-like non-depolarizing blocking properties hence may cause muscular paralysis(IPCS, 1999;Appiah-Ankam and Hunter, 2004)
• Benzalkonium chloride has brochoconstrictive properties as a result of causation of spasmogenic mediator release from the mast cells in the bronchial wall in addition to stimulation of broncho-constrictive . . .
Please Subscribe to continue reading
