- Carbendazim, chemically known as methyl benzimidazol-2-ylcarbamate, is a broad-spectrum systemic fungicide
- Carbendazim works by inhibiting β-tubulin polymerization, disrupting fungal cell mitosis, and eventually causing cell death. In humans, it causes CYP1A2-mediated bioactivation, protein adduct formation, oxidative damage, and endocrine disruption (Sivasankaryet al., 2025)
- It has low acute toxicity: Oral LD50 in rats >5000 mg/kg. Dermal LD50 in rabbits is more than 2,000 mg/kg (Sivasankaryet al., 2025)
- A combination with other fungicides and pesticides potentiates toxicity
Toxic manifestation
- Gastrointestinal irritation (nausea . . .
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