Toxicology
• As a chemical family, the thiocarbamates are a group of pesticides with a wide range of uses. Some are used as fungicides, while others have herbicidal activity (Fishel FM, 2005)
The herbicides include: butylate, cycloate, di-allate, EPTC, molinate, tri-allate
Members of this chemical family with fungicidal activity include ferbam, metam-sodium, thiram, and ziram (Fishel FM, 2005)
Thiocarbamate herbicides have shown alcohol dehydrogenase inhibitory activity and hence produces disulfiram-like effects. The s-methyl and sulfoxide metabolites are the responsible agents. The in vivo effects at 8 mg/kg on ALDH activity and 40 mg/kg on . . .
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