Carbamates are a class of insecticides structurally different, but mechanistically similar to organophosphates (OPs) insecticides. Common agents resulting in toxic exposure are aldicarb, propoxur, carbofuran, carbaryl (Sevin dudu dust™), ethinenocarb, fenobucarb, and methomyl (Lannate™).
Acute exposure to carbamates produces symptoms identical to OP toxicity. They both bind to and inhibit acetylcholinesterases (AChE)-Ops phosphorylates, carbamates carbamylates-at neuronal synapses resulting in accumulation of Ach at synapses in the CNS, at neuromuscular junctions and at effector sites-however organophosphates, they do not need to be activated (S --> O ) before becoming effective; hence carbamates act swiftly; patients may become symptomatic within . . .
Please Subscribe to continue reading
