Rabies is a viral infection transmitted in the saliva of infected mammals (dog, bat etc) through contact with open cuts or wounds in skin or mucous membranes-genitalia, eyes, nose and mouth.
Post-exposure prophylaxis-to prevent the development of clinical rabies- consists of a regimen of one dose of immunoglobulin (passive immunisation) at day 0, and full courses of rabies vaccine (active immunisation). The combination provide synergistic protection.
The protection obtaining from rabies vaccine is usually delayed by almost a week due the time required to fully generate sufficient antibodies against rabies. Consequently, rabies immunoglobulins provide interim protection by . . .
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