Bactericidal effects of gentamicin is concentration-dependent i.e. the higher the concentration in contact with a susceptible bacteria, the more the killing power.
The ototoxic and nephrotoxic effects is time-dependent. Prolonged exposure to gentamycin results in more toxicity because of a higher uptake(a suturable process) and accumulation in target organs.
Thus, a single high dose gentamycin achieves therapeutic objective with minimum health risks as it affords an effective high peak concentrations and a prolonged low trough levels
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