Toxicology
- Risperidone is a benzisoxazole compound that was approved for use in the United States in 1994 for patients with schizophrenia. It produces antagonism of serotonergic, dopamine receptor, α-adrenergic, and histamine receptors
- Risperidone is an atypical antipsychotic with strong affinity for serotonin type 2 (5-HT2A) receptors and slightly weaker affinity for dopamine type 2 (D2) receptors.
- Blockade of dopamine type 2 (D2) receptors is responsible for extrapyramidal symptoms and pathogenesis of neuroleptic malignant syndrome (NMS), disturbance of serotonin metabolism could be implicated too (Saltik and Basgul, 2012)
- α-1 adrenergic effects are . . .
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