- Afoxolaner, an isoxazoline parasiticide, kills fleas and ticks by blocking GABA-gated chloride channels in their central nervous system. This binding blocks the influx of chloride ions, which normally inhibit nerve impulses.
- This intense neural stimulation results in paralysis and eventual death of the parasite.
- Afoxolanerr shows very low potency for blocking mammalian GABA-A receptors, which minimizes the risk of toxicity in treated animals when used at recommended doses. However, neurological adverse events such as convulsions and lethargy have been reported in some animals.
- The reported oral toxicity profile of afoxolaner . . .
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