- Fluralaner is another systemic insecticide and acaricide belonging to the isoxazoline class that is orally administered to cats and dogs
- Fluralaner, an isoxazoline compound, produces toxicity in insects and arachnids by acting as a non-competitive antagonist of GABA-gated and L-glutamate-gated chloride channels in the nerve and muscle cells of arthropods ie channels activated by GABA and L-glutamate >>hyperexcitation of the insect's central nervous system, leading to uncontrolled neuronal activity, muscle tremors, ataxia (loss of coordination), paralysis, and eventually death.
- Binding to and blocking of phylogenetically related . . .
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