- Flometoquin is a novel insecticide with a structurally unique phenoxy-quinoline.
- Flometoquin's mode of action (MOA) is based on its deacylated metabolite, FloMet, which acts as a mitochondrial complex III inhibitor at the (Qi site) of mitochondrial respiratory chain complex III. Such insecticides ultimately inhibit mitochondrial oxidative phosphorylation and block ATP production which is detrimental for the survival of pests (Takeuchi et al., 2024).
- In addition to energy depletion, exposure to flometoquin can lead to oxidative stress in high-energy organs such as the liver, kidneys, heart, and brain, further contributing to its . . .
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