- Fomesafen belongs diphenyl-ether class of contact herbicides which are inhibitors of a key enzyme (protoporphyrinogen oxidase, also known as protoporphyrin IX oxidase, abbreviated as PPO) required for the production of chlorophyll in plants and mammalian heme (req higher concentrations in mammals required to inhibit heme production). This leads to an accumulation of protoporphyrin IX, a photosensitizing molecule that causes rapid cell membrane damage upon exposure to light.
- In the presence of light, these precursors in the skin become reactive oxygen species, leading to painful blistering and increased skin fragility. Indeed, Fomesafen was shown to inhibit . . .
Please Subscribe to continue reading
