- Benzhexol, aka Trihexyphenidyl, is a centrally acting muscarinic antagonist used for the treatment of Parkinsonism and drug-induced extrapyramidal disorders.
- Its toxicity is due to both peripheral and central anticholinergic effects.
- It has a wide therapeutic window. In humans, doses up to 300 mg (5 mg/kg) have been ingested without fatalities or complications.
- However, death has been reported following co-ingestion of benzhexol overdosages with other CNS-depressant agents.
- Benzhexol blood concentrations associated with the fatalities ranged from 0.03 to 0.80 mg/l.
- Trihexyphenidyl is . . .
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