Treatment of poisoning caused by pyrethroids is informed by their mechanism of action.
Pyrethroids increase neuronal excitability by not only affecting the ubiquitous voltage- sensitive sodium channels but also by blockade of chloride channels in the CNS.
Barbiturates such as phenobarbital being chloride channel agonists are useful particularly in young children experiencing severe symptoms.
It's microsomal enzyme -inducing ability ( enhances elimination) is an added advantage.
#Thursdaybit
#PoisonSenseApp4android . . .
Please Subscribe to continue reading
