Ibuprofen is usually used to relieve fever, pain and/or swelling or inflammation.
Toxicity of ibuprofen overdose results from non-specific reversible inhibition of cyclooxygenase I and II, an enzyme responsible for the synthesis of local hormones known as prostaglandins.
Toxic effects are usually seen at doses greater than 100 mg/kg; severe cases are seen at doses exceeding 400 mg/kg (~ 60 tabs, adult or 100mls, child)
Ibuprofen is rapidly absorbed orally and time to peak concentrations varies with formulation; ranges from 45-120 minutes. Liquids is the fastest while tablets are slowest.
The symptoms of overdose may include . . .
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