The molecular mode of action of halogenated salicylanilide, including closantel, niclosamide,oxyclozanide, rafoxanide and resorantel is not completely elucidated.
Salicylanilides, also referred to as benzamides or salicylamides, are weak,acidic phenolic compounds (Swan G E, 1999).
The rate of gastrointestinal absorp-tion of closantel and rafoxanide in ruminants is low;maximum plasma concentrations (Cmax) are reached in 24–48 h late (Swan G E, 1999)
Niclosamide is restricted to the gastrointestinal tract due to very poor absorption following oral administration.
Halogenated salicylanilides are highly protein bound; extensive binding to plasma albumin(>97 %) has been reported for both closantel and . . .
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