- Toxicology
After oral ingestion of benzoic acid and sodium benzoate, there is a rapid and extensive absorption (of undissociated benzoic acid) from the gastrointestinal tract. In humans, the peak plasma concentration is
reached within 1-2 h (IPCS,2000).
Benzoic acid/salt has a small volume of distribution (estimated 0.14 L/kg in neonates).
Benzoic acid is poorly absorbed by the dermal route.
In the liver, the absorbed benzoic acid is metabolized rapidly in the liver by conjugation with glycine resulting in the formation of hippuric acid. Hippuric acid is rapidly excreted in urine within . . .
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