- Albendazole is a synthetic benzimidazole with a wide spectrum coverage as an antiparasitic drug.
- The main benzimidazole derivatives used in human medicine include albendazole, flubendazole, triclabendazole, mebendazole, and thiabendazole
- Albendazole sulfoxide, the active metabolite of albendazole, causes selective degeneration of cytoplasmic microtubules of intestinal helminths and larvae. The metabolite binds to the B-tubulin subunit of the microtubules, inhibiting microtubule polymerization.
- Microtubules are important organelles involved in motility, cell division, and secretory processes in all living organisms. In the worms, the blocking of microtubules disrupts the uptake of glucose, which eventually depletes . . .
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