Warfarin was the first anticoagulant to be used against animal pests in the 1940s. With time however rodents developed resistance to it. Long-acting anticoagulants (the so-called superwarfarins) such as brodifacoum, diphenadione, chlorophacinone, and bromadiolone (eg Lanirat™) were developed to counter warfarin resistance.
Superwarfarins act indirectly by blocking vitamin K(1)-2,3-epoxide reductase enzyme involved in the regeneration of active vitamin K necessary for maturation of vitamin K-dependent clotting factors (including prothrombin and factors VII, IX and X).
Vitamin K therapy reverses the anticoagulant effect of rodenticides over a period of 24 to 48 hours from . . .
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