TOXICOLOGY
(Tri)azole fungicides includes (cyproconazole, epoxiconazole and prochloraz);triazole antifungal drugs include fluconazole, itraconazole,posaconazole and voriconazole
They have low oral toxicity and are unlikely to pose severe acute hazards.
Azole compounds reversibly bind to cytochrome P450 enzymes-lanosterol-14α-demethylase
(CYP51) and CYP19 (aromatase)-which is held responsible for their toxicological profile. The lipophilic nature of azole compounds promotes penetration and inhibition of cytochrome P450 enzymes within the endoplasmatic reticulum. Lipophilicity may also enhace dermal toxicity.
Azoles have a potential to interact with co-administered drugs. Their inhibition of xenobiotic metabolising enzymes such as CYP3A4 can lead to . . .
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