Because most absorbed toxicants are carried in the bloodstream, blood flow patterns often dictate which tissues may be affected. Within the tissues, variations in cell type and function can also influence the pattern of injury that can be seen with a given toxicant.
The liver is unusually susceptible to toxicant-induced injury due to its unique physiology and biochemistry. This is because they receive high volumes of blood flow, play a major role in metabolism and detoxification of xenobiotics.
Hepatocytes in zone 1 are the first to be exposed to toxicants that enter the liver, and these cells are injured . . .
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