Salbutamol is a selective B2-adrenoceptor agonist
Relaxes smooth muscles through increase of the intracellular cAMP
It also increases the conductance of large Ca2+-sensitive K+ channels in airway smooth muscle, leading to membrane hyperpolerization and relaxation by a mechanism independent of adenylyl cyclase activity
Stimulation of beta2-adrenergic receptors on mast cells, basophiles, eosinophils, neutrophils, and lymphocytes through increase of the intracellular cAMP, inhibits the inhibits the release of inflammatory mediators and cytokines.
Relaxes bronchial and uterine muscles; peripheral vessels are dilated, heart rate increases
Metabolic effects (e.g. decrease of the plasma potassium levels
LD50 acute studies indicated . . .
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