Key concerns for toxicity involve liver injury (hepatotoxicity) and anemia, as it disrupts heme biosynthesis, affecting the liver, bone marrow, and potentially causing endocrine disruption and cancer (classified as a possible human carcinogen).
It is structurally related to lactofen and acifluorfen which inhibits protoporphyrinogen oxidase, involved in haeme biosynthesis pathway. Oxyfluorfen inhibits haem production which results in a variety of anaemias (Pirasath et al .,2021).
Toxicity can occur through acute oral, dermal and inhalation routes (Pirasath et al .,2021).
Oxyfluorfen was shown to cause DNA fragmentation of the liver increased and increaed oxidative stress marker such a lipid peroxidation, superoxide . . .
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