Mesotrione has herbicidal activity against broadleaf weeds.
Mesotrione is a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, a key enzyme of the tyrosine catabolic pathway, resulting in increased 4-hydroxyphenyl pyruvate, the proximal tyrosine metabolite and increased blood tyrosine concentration.
HPPD inhibitors include other herbicides of the triketone family, such as sulcotrione and tembotrione, and to the pharmaceutical drug NTBC (USEPA, 2001;USEPA, 2001).
Administration of mesotrione to volunteers resulted in a transient increase in plasma tyrosine concentrations.
Mesotrione has low acute toxicity via the oral, dermal, and inhalation routes. It is a mild eyeirritant, but is not a dermal irritant or . . .
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