Adverse Effects
- About 80% of the patients will develop infusion-related adverse effects or nephrotoxicity.
- Hypokalemia
- Hypomagnesemia
- Anaphylaxis
- Nephrotoxicity: Renal toxicity correlates with conventional amphotericin B use. But the azotemia often stabilizes with therapy, and renal damage is reversible after discontinuation of amphotericin B. Avoid concomitant use of other nephrotoxic agents
- Long-term administration is associated with normochromic, normocytic anemia due to low erythropoietin concentrations.
- Fever, headache, chills, hypotension, tachypnea, and vomiting typically occur within 1 to 3 hours after initiating an intravenous infusion of amphotericin . . .
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