Toxicology
The acute oral LD50 for chloroacetamide preservative was 155 mg/kg for mice,70 to 138 mg/kg for rats, 31 mg/kg for dogs, and 122 mg/kg for rabbits. Chloroacetamide was neither an ocular nor a skin irritant when tested at 5.0% in the rabbit.
Although chloroacetamide preservative showed no sensitization in guinea pigs at test concentrations of 0.07%, 0.21%, and 1.0%, a RIPT sensitization studies indicated that chloroacetamide is a potential human sensitizer at concentrations of 0.5% and 1.25% (Final Report on the Safety Assessment of Chloroacetamide, 1991)
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