Carfentrazone-ethyl is a contact herbicide used to control broadleaf and sedge weeds in cereals.
The mode of action of carfentrazone-ethyl is the disruption of membranes by inhibiting the action of protoporphyrinogen oxidase, causing cell death.
In plants, this inhibition interferes with the chlorophyll
biosynthetic pathway. In mammals, this inhibition interferes with the heme biosynthetic pathway and results in alterations in hematological profiles and/or in increased urinary porphyrin levels and hepatotoxicity following long-term dosing.
A metabolism study in rats indicated that approximately 72.4-87% of the administered dose of carefentrazone-ethyl was rapidly absorbed and excreted . . .
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