Toxicology
• Hexythiazox is rapidly absorbed, distributed and excreted primarily in faeces ( about 70%)while the rest in urine(IPCS Inchem;EFSA, 2010)
• The oral absorption has been estimated at 30% (EFSA, 2010)
• Most of the orally administered hexythiazox is excreted as metabolites while a small proportion (about 20%) is excreted unchanged(IPCS Inchem)
• Hexythiazox is metabolized via oxidation, and finally cleavage of the cyclohexane ring(IPCS Inchem)
• Hexythiazox is unlikely to be acutely hazardous in normal use since no signs of toxicity were observed after acute oral and dermal exposure to hexythiazox (LD50 > 5000mg/kg bwt) . However, the metabolites . . .
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