Toxicology
• Inhibits the passage of chloride ions through GABA-gated chloride channels, resulting in neuronal hyper-excitability (Roberts and Reigart, 2013).
• It's rapidly absorbed from the GIT and the rapidly metabolised to the more toxic sulfone metabolite(Roberts and Reigart, 2013).
• It has a high affinity for insect (with 150-2000 fold selectivity) compared to mammalian GABA-A receptors results in lower animal toxicity and normally has a favorable outcome (Mohamed et al 2004, Lee et al 2010). The low toxicity in mammals is also due to high potency of fipronil which allows use of small quantities and low . . .
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