Fluazaindolizine

  • Fluazaindolizine is one of the new nematicides considered to have desirable toxicological and ecotoxicological characteristics . It is selectively active against plant-parasitic nematodes (PPNs) with no or little adverse effects towards non-PPNs.
  • Fluazaindolizine is a novel nematicide with unknown mode-of-action. The compound has not shown activity against acetylcholinesterase, mitochondrial electron transport, nicotinic acetylcholine receptors, glutamate-gated chloride channels (Matera et al., 2021).
  • However, in silico studies show that a possible mechanism of action of fluazaindolizine is through the inhibition of pantoate synthase responsible for the . . .

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